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Galapagos Stops Phase II RA Trial

Galapagos NV will discontinue its Phase II trial for GLPG0259 in rheumatoid arthritis (RA) following a planned interim analysis that did not support continuing development of the drug for RA.

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By: Tim Wright

Editor-in-Chief, Contract Pharma

Galapagos NV will discontinue its Phase II trial for GLPG0259 in rheumatoid arthritis (RA) following a planned interim analysis that did not support continuing development of the drug for RA. No serious adverse events or safety signals were reported, but the Interim Review Committee recommended that study be discontinued due to limited efficacy potential. Galapagos plans to complete a full analysis of the data before making a decision on the next steps for GLPG0259, including other indications.

“The innovative trial design used in this Phase II trial enabled quick determination regarding GLPG0259’s potential efficacy in RA. We will now focus on accelerating the development of our other programs and continue to leverage our unique discovery platform to bring novel modes-of-action to the clinic,” said Onno van de Stolpe, chief executive officer of Galapagos.

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